Helen Daniels
Viagra, Cialis and Levitra are all 5PDE enzyme inhibitors, and each contains its active ingredient: sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).
Erectile dysfunction can be treated effectively with these drugs. As part of this article, we will examine how they react to taking them, whether they act the same way, how long the effect lasts and whether there are any significant differences between them. The following article discusses side effects and contraindications.
It provides a therapeutic effect for approximately four hours, making it the most widely-used active ingredient. There are also popular choices, such as Cialis, known as the weekend pill because of its long-term effects lasting up to 36 hours and Levitra, which is effective for up to eight hours in some people.
Studies have shown that all four drugs can effectively treat erectile dysfunction when taken correctly and under medical supervision; however, results may vary based on individual physiology. You must consult your physician before taking these medications if you have a heart problem – such as a stroke or myocardial infarction – or any other condition where your doctor does not recommend sexual activity.
For erectile functions to occur, the vascular system, nervous system, penile anatomical structure and psychological and hormonal factors must be intact. When any of these areas are compromised, erectile dysfunction occurs. Depending on its underlying cause, impotence can be classified as vasculogenic, neurogenic, psychogenic, or hormonal. As a result, the penile corpora cavernosa is flooded with blood.
Medications like Viagra, Cialis and Levitra are usually used to treat erectile dysfunction. Viagra was the first of these medicines to be launched in 1998. All four drugs share a similar mode of action: they work by inhibiting an enzyme named PDE-5 which contributes to increased blood flow to the penis, thus producing an erection. Even though they have a common effect, they have some differences. For instance, Viagra can give results between 4 and 6 hours while Cialis performs over time – up to 36 hours – which is suitable when couples plan on having sex during the weekend or one partner requires more extended effects than the other. Additionally, Levitra usually acts faster but has fewer side effects than Viagra.
Lastly exhibits quick action (30 minutes) compared to the other remedies, but it should be appropriately utilised under medical supervision.
When treating erectile dysfunction, lifestyle tweaks are crucial. These include physical activity, reducing alcohol and tobacco use, getting enough sleep, maintaining a balanced diet and reducing stress. Additionally, it is necessary to receive psychiatric care if the cause is mental, such as depression or anxiety, as well as other therapies. Although lifestyle modifications can help restore one’s well-being, they may be difficult when you already suffer from ED.
Several molecules play a remarkable role in regulating erection, including nitric oxide (NO), which activates a chain reaction that relaxes smooth muscle cells in the penile vessels, increasing blood flow to the penis. Certain drugs can adversely affect the enzyme 5-phospho-diesterase, which reduces NO, which is essential for proper sexual function.
Sexual stimulation is the primary way nitric oxide is released into penile tissues. Since 5PDE drugs prolong the effect of nitric oxide, they cannot cause spontaneous erections. Therefore, Viagra, Cialis and Levitra won’t cause any changes if you don’t engage in sexual activity after taking them.
Incorporating physical activity into one’s routine can benefit erectile function. Regular exercise improves cardiovascular health by increasing oxygen-rich blood flow to the arteries, and it potentially reduces stress on the heart and helps keep weight down. Additionally, it releases endorphins that can help alleviate depression symptoms that are associated with ED. Therefore, exercise may serve as an effective alternative treatment for mild cases of erectile dysfunction.
Drug therapy can be deemed successful if it achieves good penetration. According to clinical trials, the four available drugs have proven efficacies ranging from 60-90%, dependent on the extent of erectile dysfunction. Although there have been no comparative studies, the results appear similar among large groups: no drug is superior to another. While one medication may work well for someone, it might not produce the same response in others; therefore, it may be beneficial to experiment with various solutions if an individual’s results are only partially satisfying.
Taking precautions to prevent anyone with underlying medical conditions from using these drugs is essential because they are easy to use, have mild side effects, or only last a short time. Despite the low number of reports of intense physical reactions, it is highly recommended that you consult a medical professional before taking any medication to treat erectile dysfunction.
Tadalafil (Cialis) takes longer to act than other 5PDE inhibitors. For Tadalafil (Cialis) to work, it may take 30-40 minutes and peaks within 2 hours. Therefore, it is important not to engage in sexual activity within 2 hours of taking the drug to ensure its effectiveness.
5PDE inhibitors can be made soluble/orodispersible whenever rapid action is required. In addition to dissolving quickly in the mouth, these substances enter circulation directly after being absorbed by mucous membranes (thereby avoiding absorption in the gastric and portal circulations). Read the article for more information. Some preparations contain sildenafil and Levitra or soluble: Siler, Rabestrom and others.
Regarding the duration of therapeutic action of these four drugs, Cialis (Tadalafil) wins: it lasts up to 36 hours! Half-life (T/2) refers to the time it takes to eliminate half of the drug. Compared to Viagra and Levitra, which last about 3 hours.
A significant advantage of Cialis is that its duration of action is not affected by dishes containing fat or citrus fruits – one of its primary advantages. Compared to Viagra and Levitra, Cialis does not need to be taken on an empty stomach to achieve the best effect, making it a more flexible option than other ED medications.
Taking drugs to treat erectile dysfunction usually requires only one dose before sex (known as “on-demand” or “on-demand” use). It is, however, possible to maintain sustained therapeutic benefits with tadalafil (Cialis) because of its pharmacokinetic properties. In addition to the cost, this therapy is recommended for those who enjoy sexual intercourse frequently and do not like planning.
Tadalafil (Cialis) is an excellent solution for addressing long-term issues involving erectile dysfunction. Its low, consistent doses mean a reliable presence of the drug in the body and no need to up the dose to get results. More expensive than other approaches, Cialis does come with its benefits, such as lessening risks related to sexual activity due to its continuous ability, plus a positive result on heart health. On top of that, studies have shown it has the added advantage of enhancing urinary symptoms and improving quality of life.
Food and alcohol can reduce the effectiveness of your products. When taking certain medications, such as sildenafil (Viagra) and vardenafil (Levitra), which are associated with 5PDE inhibition, it is necessary to take them on an empty stomach or separate them from a meal. For their efficacy to not be significantly compromised, medications should not be taken with fatty foods or alcoholic beverages. However, tadalafil (Cialis) is less affected by these factors.
It is essential to follow your healthcare provider’s instructions carefully when making dietary changes because they can affect the effectiveness of any medication. Before beginning a new treatment, inquire about the influence that food and alcohol may have on your prescriptions. Be aware of how dietary changes may affect your medications.
| Medication | Mechanism of action | Therapeutic efficacy | Speed of action | Duration of therapeutic effect | Price per tablet | Common Side Effects |
| Tadalafil (Cialis) | Inhibition of phosphodiester type 5 | 80-90% | 30-60 minutes | 36 hours | $1-$5 per tablet | Headache, nausea, muscle pain |
| Sildenafil (Viagra) | 70-80% | 4-5 hours | Headache, nausea, facial flushing | |||
| Vardenafil (Levitra) | 75-85% | 25-60 minute | $1-$4 per tablet |
Tadalafil has the most enduring effect, proving to be well-tolerated by users. Avanafil produces better results than sildenafil and vardenafil, though the impact may be fleeting. Out of the three drugs, vardenafil appears to have the most reactions associated with it. In conclusion, all medicines investigated can enable men with ED to acquire or sustain an erection during sexual activity; however, a medical doctor should be consulted before beginning any treatment for impotence, as certain concoctions could interact negatively when combined with other medications/conditions.
The four drugs available for treating erectile dysfunction (Viagra, Cialis and Levitra) have reliable efficacies ranging from 60-90%, depending on the severity of the condition. There haven’t been any comparative studies, so no drug is better. Thus, trying different medicines can be helpful if the results are unsatisfactory.
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